[Clinical significance of platelet volume indices estimated by automated blood cell analyzer]

M Ogura, M Yasuno, Y Kobayashi, T Tsukada
Rinsho Byori. the Japanese Journal of Clinical Pathology 1995, 43 (4): 385-90
Clinical significance of platelet volume indices (Platelet distribution width: PDW, Mean platelet volume: MPV, Platelet large cell ratio: P-LCR) estimated by automated blood cell analyzer (Sysmex NE-8000) was studied in 29 ITP cases and 17 cases with platelet hypoproduction which diagnosis was established by platelet kinetic study, megakaryocyte counts and the amount of platelet-associated IgG. These indices were not obtained by analyzer in 48% of 23 cases with platelet count less than 50 x 10(9)/l and 23% of 31 cases with platelet counts ranged in 50-100 x 10(9)/l. The coefficient of variation (CV) of PDW, MPV and P-LCR estimated 5 times in samples with platelet count more than 100 x 10(9)/l was 2%, 1% and 2.3%, respectively. In samples with platelet count less than 50 x 10(9)/l, CV of each index increased 3 times or more. Only four out of 22 ITP cases with platelet count less than 100 x 10(9)/l showed increased platelet volume and remaining 18 cases showed normal volume. In 12 cases with platelet hypoproduction, 3 cases showed increase of platelet volume and one case showed decrease of volume. Significant correlation was observed in between PDW and platelet survival time (r = -0.41, p < 0.05) and in between PDW and platelet turnover rate (r = 0.38, p < 0.05) in 29 ITP cases. Although the various changes of platelet volume indices during recovery phase after chemotherapy were observed in cases of acute leukemia or malignant lymphoma, these one were not a characteristic change in recovery phase of platelet under-production but rather different in each individual.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"