[Influence of the 2nd and 3rd grade abstracts from scorpion venom of Buthus martensii Karsch on action potentials of fast response myocardiocytes]

Y Jiang, W Liu, G G Zhong, S J Yang, W J Zhang, J J Wei, H J Zhang, L Wang
Zhongguo Yao Li Xue Bao, Acta Pharmacologica Sinica 1995, 16 (2): 172-4

AIM: To screen the active components of sodium channel blockade action from Buthus martensii Karsch (BMK) scorpion venom.

METHODS: Myocardiocytes of mice were cultured. Action potentials of fast response myocardiocytes were recorded. The effects of 22 contents of BMK scorpion venom in a concentration of 3 mg.L-1 were tested and compared with that of TTX 2.5 mg.L-1, nimodipine (Nim) 3 mg.L-1 and BaCl2 24.4 mg.L-1.

RESULTS: BMK-1 and other 19 contents significantly decreased depolarization parameters Vmax, APA, OS, and MDP, which was similar to that of TTX and different from that of Nim and BaCl2.

CONCLUSION: The variations in the action potentials of fast response myocardiolcytes indicated that 20 contents of BMK scorpion venom had sodium channel blockade action.

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