JOURNAL ARTICLE

Intravenous immunoglobulin infusion in multifocal demyelinating motor neuropathy: a case report

Y Y Lin, C P Tsai, Y C Ting, K P Lin, K K Liao, K P Kao, S J Wang
Zhonghua Yi Xue za Zhi, Chinese Medical Journal; Free China Ed 1995, 56 (1): 66-9
7553414
The following report is a case of multifocal demyelinating motor neuropathy (MMN) presenting as a gradual development of asymmetric motor weakness without sensory involvement. Electrophysiological studies showed mainly a conduction block with normal or slightly slow nerve conduction velocity. Cerebrospinal fluid (CSF) protein and serum protein electrophoresis were normal, but serum IgM anti-GM1 ganglioside antibody was elevated. The patient had a poor response to steroid, plasmapheresis and chemotherapy with cyclophosphamide, but significant improvement was noted after intravenous immunoglobulin (IVIG) infusion. MMN is a potentially treatable condition which clinically mimics a motor neuron disease; if treatment with steroid, plasmapheresis and cyclophosphamide have failed, IVIG may be effective.

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