We have located links that may give you full text access.
Drusen of the optic disk and aberrant axoplasmic transport. The XXXIV Edward Jackson memorial lecture.
American Journal of Ophthalmology 1978 January
We believe axoplasmic transport alteration is the anatomic substrate for formation of drusen of the optic disk. In familial cases the cause of axoplasmic transport alteration may be related to the presence of a genetically determined, small, crowded optic nerve head. We believe these congenitally elevated nerve heads evolve over a period of many years through stages of atrophy and drusen formation. Vascular malformations in the familial cases are primarily developmental; however, secondary vascular alterations may occur as the drusen enlarge. In retinitis pigmentosa the drusen may be caused by diminished production of axoplasmic material by the ganglion cell. Chronic alterations in axonal transport from any cause produce aggregates of swollen nerve fibers. These give a yellow-white appearance to the disk tissue and account for the yellow, filled-in appearance of the disk in patients with drusen, chronic atrophic papilledema, melanocytomas, and, in part, for the waxy yellow appearance of the disk in retinitis pigmentosa.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian Journal of Anaesthesia 2024 April 11
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app