OPEN IN READ APP
COMPARATIVE STUDY
JOURNAL ARTICLE

[Modification of the immune response by using an antigen bound to synthetic polyelectrolytes]

R V Petrov, V A Kabanov, R M Khaitov, M I Mustafaev, A Sh Norimov
Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii 1981, (2): 58-63
7245957
The immunogenic properties of the soluble complexes of bovine serum albumin (BSA) and synthetic polyelectrolytes were studied. The polyelectrolytes used in these complexes were 4-vinyl-N-ethylpyridinium bromide and 4-vinyl-N-cetylpyridinium bromide (complex I), 4-vinylpyridine and 4-vinyl-N-acetylpyridinium bromide (complex II). C57BL mice were immunized with different doses of BSA, complexes I and II introduced intraperitoneally in a single injection, and the number of plaque-forming cells (PFC) in the spleen was determined by modified Jerne's test with the use of BSA-covered sheep red blood cells. The above complexes were shown to stimulate the production of PFC against BSA 50-100 times more intensively than pure BSA. The mixtures of BSA with the above-mentioned polyelectrolytes stimulated PFC production to a considerably lesser extent. Thus, the polymeric part of these conjugates was not an antigen, but served as a carrier inducing pronounced immune response to the antigenic (protein) part of the complex.¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿¿

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read
7245957
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"