Among four anti-Gd cold agglutinins two showed a slight preferential reaction with p erythrocytes, two did not. Anti-Fl and anti-Sa cold agglutinins, sharing some serologic characteristics with Gd antibodies, showed no preferential reactions with p cells. The findings point to different fine specificities of monoclonal anti-Gd cold agglutinins.

Reaction of anti-Gd, anti-Fl and anti-Sa cold agglutinins with p erythrocytes.

Vox Sanguinis

Management of Latent Tuberculosis Infection.

JAMA

There is no all-encompassing or universally accepted definition of the difficult airway, and it has traditionally been approached as a problem chiefly rooted in anesthesiology. However, with airway obstruction reported as the second leading cause of mortality on the battlefield and first-pass success (FPS) rates for out-of-hospital endotracheal intubation (ETI) as low as 46.4%, the need to better understand the difficult airway in the context of the prehospital setting is clear. In this review, we seek to redefine the concept of the "difficult airway" so that future research can target solutions better tailored for prehospital, and more specifically, combat casualty care. Contrasting the most common definitions, which narrow the scope of practice to physicians and a handful of interventions, we propose that the difficult airway is simply one that cannot be quickly obtained. This implies that it is a situation arrived at through a multitude of factors, namely the Patient, Operator, Setting, and Technology (POST), but also more importantly, the interplay between these elements. Using this amended definition and approach to the difficult to manage airway, we outline a target-specific approach to new research questions rooted in this system-based approach to better address the difficult airway in the prehospital and combat casualty care settings.

The Difficult Airway Redefined.

Prehospital and Disaster Medicine

Misdiagnosis in the Emergency Department: Time for a System Solution.

Antiplatelet drugs, as the cornerstone of the treatment of coronary heart disease, control the progression of the disease, but bring a higher risk of gastrointestinal bleeding. Relevant guidelines recommend the use of proton pump inhibitors (PPIs) to minimize the risk of gastrointestinal bleeding in patients receiving dual antiplatelet therapy. But for people at low risk of gastrointestinal bleeding, the harms associated with routine use of PPIs may far outweigh the benefits. PPIs increase the risk of lower gastrointestinal bleeding, inhibit the effect of antiplatelet drugs, impair vascular endothelial function, meanwhile induce hypomagnesemia, iron deficiency, vitamins D and K deficiency, etc. Eventually, PPIs may lead to an increase in cardiovascular events. However, the situation is that PPIs are often overused. This review elucidates the mechanisms by which PPIs increase cardiovascular events, thereby reminding clinicians to rationally prescribe PPIs.

Reaction of anti-Gd, anti-Fl and anti-Sa cold agglutinins with p erythrocytes.

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Reaction of anti-Gd, anti-Fl and anti-Sa cold agglutinins with p erythrocytes.

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