Clinical Trial
Controlled Clinical Trial
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Possible prevention of neural-tube defects by periconceptional vitamin supplementation.

Lancet 1980 Februrary 17
Women who had previously given birth to one or more infants with a neural-tube defect (NTD) were recruited into a trial of periconceptional multivitamin supplementation. 1 of 178 infants/fetuses of fully supplemented mothers (0.6%) had an NTD, compared with 13 of 260 infants/fetuses of unsupplemented mothers (5.0%).

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