We have located links that may give you full text access.
CASE REPORTS
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
Pure red blood cell aplasia associated with chronic Epstein-Barr virus infection: evidence for T cell-mediated suppression of erythroid colony forming units.
Journal of Laboratory and Clinical Medicine 1984 December
A prominent T cell suppressor response is known to develop and inhibit the polyclonal B cell activation induced by Epstein-Barr virus infection. Exuberant T suppressor cell activity suppressing erythropoiesis has been demonstrated in certain cases of pure red blood cell aplasia. We studied a 19-year-old man who developed pure red cell aplasia after Epstein-Barr virus infection. Over a 70-week period, lymphocyte function and serologic evidence for chronic Epstein-Barr virus infection was demonstrated. On two separate occasions, no evidence for serum inhibition of bone marrow erythroid colony formation in methylcellulose was observed. Growth of granulocyte-macrophage progenitors from the patient's bone marrow was normal. The patient's bone marrow cultures yielded 81.6 +/- 11.2 erythroid colony-forming units per 10(5) bone marrow mononuclear cells, which was approximately 50% of levels in normal control bone marrow. Culture of peripheral blood mononuclear cells for erythroid burst-forming units revealed minimal growth (less than 1% of control values). Depletion of bone marrow T cells by E-rosetting resulted in a threefold increase in erythroid colony-forming units in the patient's bone marrow but no significant increase from control bone marrow. In the patient, addition of bone marrow T cells but not peripheral blood T cells significantly suppressed autologous erythroid colony-forming unit proliferation from T cell-depleted bone marrow. These results suggest that the pure red cell aplasia associated with chronic Epstein-Barr virus infection in this case was caused by bone marrow T cell-mediated suppression of erythroid colony-forming unit proliferation.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app