Cold agglutinin autoimmune hemolytic anemia in nonhematologic malignancies

J Wortman, W Rosse, G Logue
American Journal of Hematology 1979, 6 (3): 275-83
Four patients with nonhematologic malignancies had the simultaneous finding of hemolytic anemia due to high-titer cold agglutinins. In each patient, the cold agglutinin had "anti-I" specificity and was of the IgM kappa immunoglobulin class. Although patients with hematologic malignancies not uncommonly have cold agglutinins, the association between these antibodies and nonhematologic malignancies is unusual.

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