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RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
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Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract.

H H Schaumburg, P S Spencer
Science 1978 January 14
2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.

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