[The regulation of bone remodeling].

The adult skeleton is subject to a remodeling process which must be tightly regulated to keep bone mass constant. Bone resorption and bone formation are coupled. After a brief review of the cellular mechanisms of bone remodeling, its regulation is discussed. Bone resorption is modulated by parathyroid hormone, 1,25-dihydroxyvitamin D and other hormones. Locally, agents such as prostaglandins and factors from the immune system are important. Bone formation is stimulated by insulin and somatomedin C (= insulin like growth factor 1) which mediates the effect of growth hormone. Other hormones and local factors also play a role.