JOURNAL ARTICLE

MPTP primate model of Parkinson's disease: a mechanographic and electromyographic study

D Doudet, C Gross, P Lebrun-Grandie, B Bioulac
Brain Research 1985 May 27, 335 (1): 194-9
3873977
Movement parameters and electromyographic (EMG) studies were carried out in two macaque monkeys performing a rapid arm movement before and after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Hypokinesia and rigidity were seen after repeated doses. Disturbances in both movements and EMG activity were similar to those reported in Parkinsonian patients.

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