Add like
Add dislike
Add to saved papers

Prognostic significance of 68  Ga-FAPI PET/CT in patients with bone metastases in various cancers.

OBJECTIVE: This study aimed to compare 18 FDGPET/CT in patients who develop bone metastases due to various cancers and to investigate the prognostic significance of the 68 FAPI-PET/CT SUVmax value for survival.

METHODS: Patients with bone metastases who underwent both 68  Ga-FAPI PET/CT and 18 FDGPET/CT within a 1 week period were included in this retrospective study. The effect of the SUVmax value of bone lesions on overall survival was analyzed.

RESULTS: A total of 75 eligible patients with 139 bone lesions were included in this study. The median age of the patients was 55 (30-83) and 48(64%) patients were newly diagnosed. The primary lesion median 68  Ga-FAPI PET/CT SUVmax value was higher than the median 18 FDGPET/CT SUVmax (10.75 versus 6.7). Bone lesions 68  Ga-FAPI PET/CT SUVmax median (IQR) were 7.8 (4.6-13.2), and 18 FDGPET/CT SUVmax of bone lesions were 5.9 (3.8-8.2). More bone lesions were detected on 68  Ga-FAPI PET/CT than on 18 FDGPET/CT(median IQR 4 [1-9] versus 2 [1-6] (p = 0.014). The extra lesions observed on 68  Ga-FAPI PET/CT were mostly sclerotic bone lesions (p = 0.001).68  Ga-FAPI PET/CT SUVmax was significantly higher in vertebra and thorax lesions (p = 0.011 and p = 0.018, respectively). While the bone lesion 68  Ga-FAPI PET/CT SUVmax affected the OS, the 18 FDGPET/CT SUVmax value did not affect the OS (p < 0.001 and p = 0.079, respectively). In ROC analysis, a cut-off-off value of 68  Ga-FAPI PET/CT SUVmax > 7.7 was found for OS (AUC: 0.619). The median OS in the group above the cut-off value was worse than that in the group below the cut-off value (32 versus 45) months (p = 0.002). In the multivariate analysis for OS, the 68  Ga-FAPI PET/CT SUVmax of bone lesions was an important parameter, as well as cancer subtype, ALP level, and disease occurrence.

CONCLUSIONS: 68  Ga-FAPI PET/CT detected more bone lesions and higher SUVmax values than 18 FDGPET/CT in various cancers. The prognostic value of the SUVmax value of 68  Ga-FAPI PET/CT bone lesions was observed regardless of disease subtype.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

Related Resources

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app