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Decoding epitranscriptomic regulation of viral infection: mapping of RNA N 6 -methyladenosine by advanced sequencing technologies.

Elucidating the intricate interactions between viral pathogens and host cellular machinery during infection is paramount for understanding pathogenic mechanisms and identifying potential therapeutic targets. The RNA modification N6 -methyladenosine (m6 A) has emerged as a significant factor influencing the trajectory of viral infections. Hence, the precise and quantitative mapping of m6 A modifications in both host and viral RNA is pivotal to understanding its role during viral infection. With the rapid advancement of sequencing technologies, scientists are able to detect m6 A modifications with various quantitative, high-resolution, transcriptome approaches. These technological strides have reignited research interest in m6 A, underscoring its significance and prompting a deeper investigation into its dynamics during viral infections. This review provides a comprehensive overview of the historical evolution of m6 A epitranscriptome sequencing technologies, highlights the latest developments in transcriptome-wide m6 A mapping, and emphasizes the innovative technologies for detecting m6 A modification. We further discuss the implications of these technologies for future research into the role of m6 A in viral infections.

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