The Role of Contrast-Enhanced Mammography After Cryoablation of Breast Cancer.

Image-guided cryoablation is an emerging therapeutic technique for the treatment of breast cancer and is an effective alternate treatment strategy to surgery in select patients. Tumor features impacting efficacy of cryoablation include size, location in relation to skin, and histology (e.g., extent of intraductal component), underscoring the importance of imaging for staging and workup in this patient population. Contrast-enhanced mammography (CEM) has increasing utilization in both the screening and diagnostic settings and may be useful for follow-up imaging after breast cancer cryoablation related to high sensitivity for cancer detection and advantages in PPV, time, cost, eligibility, and accessibility compared to contrast-enhanced MRI. This Clinical Perspective describes the novel use of CEM after breast cancer cryoablation, highlighting advantages and disadvantages of CEM compared to alternate imaging modalities, expected benign postablation CEM findings, and CEM findings suggestive of residual or recurrent tumor.