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Near-full-length genome analysis of a HIV-1 CRF01_AE/B recombinant strain among men who have sex with men in Chengde City, China.

The unique recombinant form (URF) of HIV is formed by multiple subtypes which are co-circulating in some area, and the number of HIV recombinants is on the increase worldwide. In this study, we identified a URF named 2019638, composed of CRF01_AE and subtype B, in a man who has sex with men (MSM) in Qinhuangdao, Hebei province, China. The near-full-length genome (NFLG) sequence was confirmed to be a novel URF. within this NFLG, two CRF01_AE fragments were inserted into the pol and vif regions, respectively, using subtype B as the backbone. Moreover, the presence of the V106M and V179D point mutations in the reverse transcriptase (RT) region rendered the high-level resistance to EFV and NVP,intermediate resistance to DOR. Our findings suggest that the HIV epidemic is evolving toward a high degree of recombination and we need to continuously monitor HIV genetic diversity to control the further development of the AIDS epidemic.

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