Single-use negative pressure wound therapy versus conventional dressings for the reduction of surgical site infections in closed surgical incisions: Systematic literature review and meta-analysis.

BACKGROUND: To evaluate whether a single-use negative pressure wound therapy (sNPWT) device can reduce the incidence of surgical site infection (SSI) in at-risk patients with closed surgical incisions across a range of surgical specialties, compared with standard care.

METHODS: PubMed, Embase, Cochrane Library and ClinicalTrials.gov were searched from the period January 2011 to April 2021.

RESULTS: Out of 15,283 articles identified, 19 were included. A statistically significant improvement (p ​< ​0.05) in the composite SSI (odds ratio [OR]: 0.36; 95 ​% confidence interval [CI]: 0.27-0.49), superficial SSI (OR: 0.30; 95 ​% CI: 0.17-0.53), and deep SSI (OR: 0.67; 95 ​% CI: 0.46-0.96) outcomes was observed with the sNPWT device compared with standard care in a pooled analysis of all surgical specialties.

CONCLUSION: A -80 ​mmHg sNPWT device reduces the incidence of composite, superficial, and deep SSIs when compared with standard care across a heterogenous at-risk surgical population containing a variety of surgical specialties.