We have located links that may give you full text access.
Return to Fertility, Toxicology, and Transgenerational Impact of Treatment with WIN 18,446, a Potential Male Contraceptive, in Mice.
Contraception 2023 October 7
OBJECTIVES: We examined the return to fertility and transgenerational impact of treatment with WIN 18,446, an experimental male contraceptive, in mice.
STUDY DESIGN: We paired male mice treated with WIN 18,446 for 4 weeks to suppress spermatogenesis followed by a nine-week recovery and mated them with normal females to assess fertility. F1 generation mice were subsequently mated to ascertain any transgenerational impact of treatment on fertility. Testes were examined histologically.
RESULTS: WIN 18,446 treated mice and their progeny produced normally sized litters (6.5 pups/litter after treatment and 7.3 pups/litter from the progeny). However, testes histology revealed rare residual intratesticular foci of mineralization after treatment.
CONCLUSIONS: Fertility normalizes after WIN 18,446 treatment and progeny also have normal fertility.
STUDY DESIGN: We paired male mice treated with WIN 18,446 for 4 weeks to suppress spermatogenesis followed by a nine-week recovery and mated them with normal females to assess fertility. F1 generation mice were subsequently mated to ascertain any transgenerational impact of treatment on fertility. Testes were examined histologically.
RESULTS: WIN 18,446 treated mice and their progeny produced normally sized litters (6.5 pups/litter after treatment and 7.3 pups/litter from the progeny). However, testes histology revealed rare residual intratesticular foci of mineralization after treatment.
CONCLUSIONS: Fertility normalizes after WIN 18,446 treatment and progeny also have normal fertility.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2025 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices 
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app