JOURNAL ARTICLE
REVIEW
Add like
Add dislike
Add to saved papers

Evolution of Lymphoma Diagnosis in the Era of Personalized Medicine - A Marriage of Pathology and Genomics for Clinical Practice.

The modern taxonomy of disease builds a framework for precision medicine, by which traditional pathological criteria are integrated with clinical and genomic features to define disease entities. Two of the most common subtypes of lymphoma on a worldwide basis are follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). While the BCL2 translocation is the signature lesion of most nodal FL, recent studies have identified significant diversity among follicle-center derived lesions. BCL2-negative FL is a genetically heterogeneous disease that occurs in both nodal and extranodal sites. Several distinct entities have been recognized in the pediatric age group including pediatric-type FL, testicular FL, and IRF4-rearranged large B-cell lymphoma. DLBCL is a family of aggressive B-cell neoplasms with marked variation in pathogenesis and clinical features. Gene expression profiling (GEP) more than 20 years ago identified the cell of origin (COO) as a key discriminator, but more recently high throughput sequencing has identified highly varied mutational profiles that should point the way in the future towards improvements in targeted therapy and patient outcome.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app