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PD-L1 and CD58 co-regulated by CMTM6 play yin and yang to shape anti-tumor immunity.

Cancer Cell 2023 October 10
The CD58-CD2 axis regulates T cell-mediated cancer immunity, but little is known about the regulation of CD58. In two recent papers pubished in Cancer Cell, Miao et al. and Ho et al. define a mechanism of CD58 regulation by CMTM6 and show an unexpected yin-yang link between PD-L1 and CD58.

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