Cost-effectiveness and diagnostic accuracy of focused cardiac ultrasound in the pre-participation screening of athletes: the SPORT-FoCUS Study.

BACKGROUND: The role of Pre-participation screening (PPS) modalities in preventing sudden cardiac death (SCD) in athletes is debated due to a high false positive rate. Focused Cardiac Ultrasound (FoCUS) has shown higher sensitivity and specificity, but its cost-effectiveness remains uncertain. This study aimed to determine the diagnostic performance and cost-effectiveness of FoCUS use in PPS.

METHODS: 2111 athletes (77.4% male, mean age 24.9±15,2years) underwent standardized family and medical history collection (MH), physical examination (PEX), resting ECG, FoCUS (10min/5views-protocol), comprehensive Echocardiography and exercise stress test(EST). We prospectively evaluated three PPS incremental models: Model-A = standardized MH and physical examination; Model-B = Model-A plus resting and stress-ECG; Model-C = Model-B plus FoCUS (10min/5views-protocol). We determined their incremental diagnostic accuracy and cost-effectiveness ratio.

RESULTS: 30 athletes were diagnosed with a cardiac condition associated with SCD: 3 were identified by Model-A, 14 by Model-B, 13 athletes by Model-C. The introduction of FoCUS markedly increased the Sensitivity of PPS, compared with model-A and model-B (Sensitivity 94% vs. 19% vs. 58%, Specificity 93% vs. 93% vs. 92%). The total screening cost (TSC) were: Model-A 35.64Eur, Model-B 87.68Eur and Model-C 120.89Eur. Considering the sole conditions at risk of SCD, the Incremental Cost Effectiveness Ratio was 135.62Eur for model-B and 114.31 for model-C.

CONCLUSIONS: The implementation of FoCUS into the PPS allows to identify a significantly greater number of athletes at risk of SCD and markedly lowers the false negative rate. Furthermore, the incorporation of FoCUS into the screening process has shown to be cost-effective.