Add like
Add dislike
Add to saved papers

In vitro toxicity of cinnamaldehyde and nanoemulsion of cinnamaldehyde on protoscoleces of hydatid cyst.

Cystic echinococcosis is a major parasitic and zoonotic disease and surgery is the most common treatment of this disease which carries the risk of intraoperative leakage and recurrence. Using scolicidal agent to inactivate cyst contents reduces the risk of recurrence. Considering side effects of available scolicidals and growing interests on natural pharmaceuticals, the present study aimed to evaluate toxicity of cinnamaldehyde (CA), the main component of cinnamon essential oil, and a developed nanoemulsion of cinnamaldehyde (nano-CA) on protoscoleces of hydatid cyst. Nanoemulsion was prepared by the low energy system and characterized by dynamic light scattering to confirm dimensions. For evaluation of scolicidal effects, serial dilutions of CA and nano-CA were mixed with protoscolices suspension and mortality were recorded at 10, 30, and 60 minutes by eosin exclusion test. Albendazole was used as the positive control. The mean diameter of nano-CA was characterized as equal to 88.5 nm, and poly dispersity index was 0.09. After 30 min of treatment, nano-CA, at 50 μg/ml, killed 99.33% of protoscoleces. At the same time point and concentration, CA only caused mortality rate of 26.18%. 30 min-LC50 value of 369.39 μg/ml was obtained for CA, while after 30 min of exposure, nano-CA showed promising rapid activity with LC50 value of 3.22 μg/ml. Nano formulation significantly increased scolicidal activity of CA probably by increasing penetration and tegumental disorganization of protoscoleces. Further in vivo safety studies are needed to introduce nano-CA as a clinically applicable scolicidal agent.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

Related Resources

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app