Add like
Add dislike
Add to saved papers

The Effects of Calcium Hydroxide-loaded Poly(Lactic-co-glycolic Acid) Biodegradable Nanoparticles in the ex vivo External Inflammatory Root Resorption Model.

AIM: To evaluate the calcium ions (Ca2+ ) diffusion of calcium hydroxide-loaded poly(lactic-co-glycolic acid) biodegradable nanoparticles [Ca(OH)2 -loaded PLGA NPs] compared with conventional Ca(OH)2 in a simulated external root resorption ex vivo model using inductively coupled plasma mass spectrometry (ICP-MS).

MATERIALS AND METHODS: Thirty human mandibular premolars were prepared by sectioning the root segments to create roots measuring 10 mm from the anatomical apex. The root canals were instrumented and irrigated. The external root surface cavities were created. The specimens were randomly divided into the following three groups: Poly(lactic-co-glycolic acid) (PLGA; control group, n = 10), conventional calcium hydroxide [Ca(OH)2 ] (Metapaste, n = 10), and Ca(OH)2 -loaded PLGA NPs [15% Ca(OH)2 , n = 10]. The intracanal materials were placed in the root canals, and the teeth were stored in phosphate-buffered saline at 37°C. The release of Ca2+ was measured at 7, 30, and 60 days using ICP-MS.

RESULTS: Both Ca(OH)2 -loaded PLGA NPs and Metapaste groups exhibited higher levels of Ca2+ release compared to the PLGA group at all time points. During the initial 7-day period, the Ca(OH)2 -loaded PLGA NPs exhibited a significantly greater release of Ca2+ compared to Metapaste. From day 7 to day 30, Metapaste displayed a significantly higher release of Ca2+ than the Ca(OH)2 -loaded PLGA NPs, but it experienced a subsequent decline in Ca2+ release after the 30-day period. After the 30-day mark, the Ca(OH)2 -loaded PLGA NPs once again exhibited a significantly higher release of Ca2+ compared to Metapaste.

CONCLUSION: The Ca(OH)2 -loaded PLGA NPs exhibited sustained release of Ca2+ that exceeded conventional Ca(OH)2 , particularly during the first week, demonstrating a greater amount of Ca2+ release.

CLINICAL SIGNIFICANCE: The utilization of Ca(OH)2 -loaded PLGA NPs as an intracanal medication for external inflammatory root resorption provided sustained release and had the potential to enhance the efficacy of inhibiting root resorption more effectively than conventional Ca(OH)2 .

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Group 7SearchHeart failure treatmentPapersTopicsCollectionsEffects of Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Patients With Heart Failure Importance: Only 1 class of glucose-lowering agents-sodium-glucose cotransporter 2 (SGLT2) inhibitors-has been reported to decrease the risk of cardiovascular events primarily by reducingSeptember 1, 2017: JAMA CardiologyAssociations of albuminuria in patients with chronic heart failure: findings in the ALiskiren Observation of heart Failure Treatment study.CONCLUSIONS: Increased UACR is common in patients with heart failure, including non-diabetics. Urinary albumin creatininineJul, 2011: European Journal of Heart FailureRandomized Controlled TrialEffects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.Review

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

Read by QxMD is copyright © 2021 QxMD Software Inc. All rights reserved. By using this service, you agree to our terms of use and privacy policy.

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app