Neuroimmune Control of Inflammation in Acute Kidney Injury: From Mouse Models to Human Disease.

Inflammation is common in patients with acute kidney injury (AKI) and contributes to increased risk of morbidity and mortality. The central nervous system plays an important role in the immune and inflammatory pathways of AKI. In this review, we discuss the preclinical evidence for the neural pathways associated with neuromodulation in AKI and their clinical implications, as well as clinical trials that translate these observations into the clinical context. The ultimate goal of these trials is to design strategies using non-invasive approaches, such as splenic pulsed ultrasonography, to prevent or attenuate inflammatory conditions at the bedside, including AKI.