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A novel, bioinformatically informed highly sensitive NAAT assay for the diagnosis of loiasis and its use for detection of circulating cell free DNA.
Journal of Infectious Diseases 2023 May 28
Mass drug administration programs targeting filarial infections depend on diagnostic tools that are sensitive and specific. The co-endemicity of Loa loa with other filarial species often hampers the control programs. LL2634 was identified as the most promising target among several highly repeated targets, with sensitivity between 500 ag and 1 fg of genomic DNA. Using DNA from infected individuals, LL2643 qPCR was positive in all individuals. LL2643 was detected in plasma derived circulating cell-free DNA (ccfDNA) from 48 of 53 mf positive patients. Detection of ccfDNA in the urine was possible, but it occurred rarely among those tested. Importantly, LL2643 ccfDNA became undetectable within 1-month following diethylcarbamazine treatment and remained negative for at least a year. LL2643 offers a more sensitive and specific target for detection of Loa loa infection and would be easily configurable to a point of contact assay.
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