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The development and function of human monocyte-derived dendritic cells regulated by metabolic reprogramming.
Journal of Leukocyte Biology 2023 May 27
Human monocyte-derived dendritic cells (moDCs) develop from monocytes play a key role in innate inflammatory responses as well as T-cell priming. Steady-state moDCs regulate immunogenicity and tolerogenicity by changing metabolic patterns to participate in the body's immune response. Increased glycolytic (Gly) metabolism after danger signal induction may strengthen moDCs' immunogenicity, whereas high levels of mitochondrial oxidative phosphorylation (OXPHOS) were associated with the immaturity and tolerogenicity of moDCs. In this review, we will discuss what is currently known about differential metabolic reprogramming of human moDCs development and distinct functional properties.
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