EPIDEMIOLOGY OF GENES ASSOCIATED WITH OBESITY IN ASIAN POPULATION. LITERATURE REVIEW.

Among the general population, there is a category of individuals with an innate predisposition to obesity. In recent decades, the increase in the prevalence of obesity and related diseases worldwide indicates the need to study the etiological factors associated with its development. At present, it is still unknown how many genes are involved in the pathophysiology of obesity, and many studies are underway to identify "candidate genes" in clinical medicine. The detection of obesity by molecular genetic diagnostics and the implementation of appropriate preventive measures can significantly reduce the incidence. Considering that the majority of people suffering from metabolic diseases are members of the working population, the prevention of these diseases and early diagnosis are of both clinical and social and economic importance. The aim of this study is to analysis of data on the most significant genetic markers in the development of obesity in the Asian population. An online search for literature on genetic markers associated with the development of obesity was conducted in the databases Elibrary, Google Scholar, PubMed, Web of Science databases was carried out. The study of genetic markers and their determination has great prospects for the successful verification of the main clinical and biological markers of obesity. This will allow assessing the risks of developing obesity and developing standards for corrective measures for individuals with a high genetic risk. Most of the GWAS studies have been conducted in the European population, the discovery of new genes in the Asian population has made a significant contribution to the identification of loci of predisposition to obesity. identification of polymorphic variants of candidate genes that are most significant in the development of this disease is an urgent task for both fundamental science and practical medicine.