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Serum Bilirubin Levels and Disease Severity in Patients with Pneumoconiosis.

AIM: To investigate the association between serum bilirubin and disease severity in patients with pneumoconiosis.

METHODS: The study comprised 45 patients with pneumoconiosis retrospectively; all pneumoconiosis patients were classified into I, II, and III stage according to the radiological severity.

RESULTS: Serum direct bilirubin levels were significantly lower in III stage pneumoconiosis patients than those in I/II stage ( p  = 0.012) but not serum indirect bilirubin. Serum direct bilirubin was negatively correlated with radiological severity in patients with pneumoconiosis ( r  = -0.320; p  = 0.032); by multiple linear-regression analysis, we observed that serum direct bilirubin levels had independent association with radiological severity in patients with pneumoconiosis (beta = -0.459; p  = 0.005).

CONCLUSIONS: Serum direct bilirubin levels are negatively associated with disease severity in patients with pneumoconiosis.

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