We have located links that may give you full text access.
Associations between maternal and infant selenium status and child growth in a birth cohort from Dhaka, Bangladesh.
British Journal of Nutrition 2023 March 22
Deficiency of essential trace element, selenium, has been implicated in adverse birth outcomes and in child linear growth because of its important role in redox biology and associated antioxidant effects. We used data from a randomized controlled trial conducted among a cohort of pregnant and lactating women in Dhaka, Bangladesh to examine associations between selenium biomarkers in whole blood (WBSe), serum and selenoprotein P (SEPP1) in maternal delivery and venous cord (VC) blood. Associations between selenium biomarkers, birth weight and infant growth outcomes (age adjusted length, weight, head circumference and weight-for-length z-scores) at birth, one, and two years of age were examined using regression analyses.WB and serum selenium were negatively associated with birth weight (adjusted β, 95% CI: WBSe delivery: -26.6 (-44.3, -8.9); WBSe VC: -19.6 (-33.0, -6.1)); however, delivery SEPP1 levels (adjusted β: -37.5 (-73.0, -2.0)) and VC blood (adjusted β: 82.3 (30.0, 134.7)) showed inconsistent and opposite associations with birth weight. Positive associations for SEPP1 VC suggest preferential transfer from mother to fetus. We found small associations between infant growth and WBSe VC (LAZ β, 95% CI, at birth: -0.05 (-0.1, -0.01)); 12-months (β: -0.05 (-0.08, -0.007)). WAZ also showed weak negative associations with delivery WBSe (at birth: -0.07 (-0.1, -0.02); 12-months: -0.05 (-0.1, -0.005)) and in WBSe VC (at birth: -0.05 (-0.08, -0.02); 12-months: -0.05 (-0.09, -0.004)). Given the fine balance between essential nutritional and toxic properties of selenium, it is possible that WB and serum selenium may negatively impact growth outcomes, both in utero and postpartum.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app