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GENLIB: new function to simulate haplotype transmission in large complex genealogies.

Mohan Rakesh, Hélène Vézina, Catherine Laprise, Ellen E Freeman, Kelly M Burkett, Marie-Hélène Roy-Gagnon
Bioinformatics 2023 March 18
SUMMARY: Founder populations with deep genealogical data are well suited for investigating genetic variants contributing to diseases. Here, we present a major update of the genealogical analysis R package GENLIB, centered around a new function which can simulate the transmission of haplotypes from founders to probands along very large and complex user-specified genealogies.

AVAILABILITY AND IMPLEMENTATION: The latest update of the GENLIB package (v1.1.9) contains the new gen.simuHaplo() function and is available on the CRAN repository and from https://github.com/R-GENLIB/GENLIB. Examples can be accessed at https://github.com/R-GENLIB/simuhaplo_functions.

SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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