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S100A9 drives the chronification of psoriasiform inflammation by inducing IL-23/type 3 immunity.
Journal of Investigative Dermatology 2023 March 14
Psoriasis is a chronic inflammatory skin disorder driven by IL-23/type-3 immune response. However, molecular mechanisms sustaining the chronicity of inflammation and psoriatic lesions remain elusive. Combining systematic analyses of several transcriptomic datasets, we delineated gene signatures across human psoriatic skin, identifying S100A9 as one of the most up-regulated genes, confirmed in lesioned skin from psoriasis patients and preclinical psoriasiform skin inflammation models. Genetic ablation or pharmacological inhibition of S100A9 alleviated Aldara-induced skin inflammation. By single-cell mapping of human psoriatic skin and bone-marrow chimeric mice experiments, we identified keratinocytes as the major source of S100A9. Mechanistically, S100A9 induced IL-23 production by dendritic cells, driving the IL-23/type-3 immunity in psoriasiform skin inflammation. Besides, the cutaneous IL-23/IL-17 axis induced epidermal S100A9 expression in human and experimental psoriasis. Thus, we demonstrated an autoregulatory circuit between keratinocyte-derived S100A9 and IL-23/type-3 immunity during psoriasiform inflammation, identifying a crucial function of S100A9 in the chronification of psoriasis.
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