Prescription of antibiotics by general practitioners in patients with a diagnosis of SARS- CoV-2 infection: analysis of an electronic French health record.

OBJECTIVE: To define the factors associated with overprescription of antibiotics by general practitioners for patients diagnosed with COVID-19 during the first wave.

METHODS: Anonymized electronic prescribing records of 1370 physicians were analyzed. Diagnosis and prescriptions were retrieved. The initiation rate by physician for 2020 was compared to 2017-2019. Prescribing habits of physicians who initiated antibiotics for more than 10% of COVID-19 patients were compared to those who did not. Regional differences in prescribing habits of physicians who have seen at least one COVID-19 patient were also analyzed.

RESULTS: For the March-April 2020 period, physicians who initiated antibiotics for more than 10% of COVID-19 patients had more consultations than those who did not. They also prescribed antibiotics more frequently for non-COVID-19 patients consulting with rhinitis. They also prescribed broad-spectrum antibiotics more frequently for treatment of cystitis. Finally, doctors in Île-de-France region saw more COVID-19 patients and initiated antibiotics more frequently. General Practitioners in southern France had a higher but non-significant ratio of azithromycin initiation rate over total antibiotics initiation rate.

CONCLUSION: We identified a subset of physicians with overprescribing profile not only for COVID-19 but also for other viral infection, and also with a tendency to prescribe broad spectrum antibiotics for a long duration. There were also regional differences concerning antibiotics initiation rate and the ratio of azithromycin prescribed. It will be necessary to evaluate the evolution of prescribing practices during subsequent waves.