We have located links that may give you full text access.
Journal Article
Review
Function and regulation of GPR84 in human neutrophils.
British Journal of Pharmacology 2023 March 5
Human neutrophils belong to the innate immune system and are the most abundant white blood cells in circulation. They are professional phagocytes and express several G protein-coupled receptors (GPCRs) which are essential for proper neutrophil functions. So far, the two formyl peptide receptors (FPR1 and FPR2) have been the most extensively studied group of neutrophil GPCRs, but recently a new group, the free fatty acid sensing receptors (FFARs), has gained growing attention. Neutrophils express GPR84 and FFA2 (sensing medium- and short-chain fatty acids, respectively) which display similar activation profiles. The exact pathophysiological role of GPR84 is not yet fully understood, but it is generally regarded as a pro-inflammatory receptor that mediate neutrophil activation. In this review, we summarize current knowledge of how GPR84 affects human neutrophil functions and discuss the regulatory mechanisms that control these responses, focusing on the similarities and differences in comparison to the two FPRs and FFA2.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app