We have located links that may give you full text access.
Multimorbidity and functional disability among older adults - the role of inflammation and glycemic status: An Observational Longitudinal Study.
Gerontology 2023 March 2
INTRODUCTION: Specific multimorbidity combinations, in particular those including arthritis, stroke, and cognitive impairment, have been associated with high burden of ADL-IADL disability in older adults. The biologic underpinnings of these associations are still unclear.
METHODS: Observational longitudinal study using data from the Health & Retirement Study (N=8,618, mean age=74 years, 58% female, 25% non-White) and negative binomial regression models stratified by sex to evaluate the role of inflammatory and glycemic biomarkers (high-sensitivity C-reactive protein (hs-CRP) and HbA1c) in the association between specific multimorbidity combinations (grouped around one of eight index diseases: arthritis, cancer, cognitive impairment, diabetes, heart disease, hypertension, lung disease, and stroke; assessed between 2006-2014) and prospective ADL-IADL disability (2 years later, 2008-2016). Results were adjusted for sociodemographic characteristics, body-mass index, number of coexisting diseases, and baseline ADL-IADL score.
RESULTS: Multimorbidity combinations indexed by arthritis (IRR=1.1, 95%CI=1.01-1.20), diabetes (IRR=1.19, 95%CI=1.09-1.30), and cognitive impairment (IRR=1.11, 95%CI=1.01-1.23) among men, and diabetes-indexed multimorbidity combinations (IRR=1.07, 95%CI=1.01-1.14) among women were associated with higher ADL-IADL scores at increasing levels of HbA1c. Across higher levels of hs-CRP, multimorbidity combinations indexed by arthritis (IRR=1.06, 95%CI=1.02-1.11), hypertension (IRR=1.06, 95%CI=1.02-1.11), heart disease (IRR=1.06, 95%CI=1.01-1.12), and lung disease (IRR=1.14, 95%CI=1.07-1.23) were associated with higher ADL-IADL scores among women, while there were no significant associations among men.
DISCUSSION/CONCLUSION: The findings suggest potential for anti-inflammatory management among older women and optimal glycemic control among older men with these particular multimorbidity combinations as focus for therapeutic/preventive options for maintaining functional health.
METHODS: Observational longitudinal study using data from the Health & Retirement Study (N=8,618, mean age=74 years, 58% female, 25% non-White) and negative binomial regression models stratified by sex to evaluate the role of inflammatory and glycemic biomarkers (high-sensitivity C-reactive protein (hs-CRP) and HbA1c) in the association between specific multimorbidity combinations (grouped around one of eight index diseases: arthritis, cancer, cognitive impairment, diabetes, heart disease, hypertension, lung disease, and stroke; assessed between 2006-2014) and prospective ADL-IADL disability (2 years later, 2008-2016). Results were adjusted for sociodemographic characteristics, body-mass index, number of coexisting diseases, and baseline ADL-IADL score.
RESULTS: Multimorbidity combinations indexed by arthritis (IRR=1.1, 95%CI=1.01-1.20), diabetes (IRR=1.19, 95%CI=1.09-1.30), and cognitive impairment (IRR=1.11, 95%CI=1.01-1.23) among men, and diabetes-indexed multimorbidity combinations (IRR=1.07, 95%CI=1.01-1.14) among women were associated with higher ADL-IADL scores at increasing levels of HbA1c. Across higher levels of hs-CRP, multimorbidity combinations indexed by arthritis (IRR=1.06, 95%CI=1.02-1.11), hypertension (IRR=1.06, 95%CI=1.02-1.11), heart disease (IRR=1.06, 95%CI=1.01-1.12), and lung disease (IRR=1.14, 95%CI=1.07-1.23) were associated with higher ADL-IADL scores among women, while there were no significant associations among men.
DISCUSSION/CONCLUSION: The findings suggest potential for anti-inflammatory management among older women and optimal glycemic control among older men with these particular multimorbidity combinations as focus for therapeutic/preventive options for maintaining functional health.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian Journal of Anaesthesia 2024 April 11
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app