Characteristics and graft outcomes of kidney transplant candidates with enteric risk factors and elevated plasma oxalate levels.

INTRODUCTION: This study describes patient characteristics and examines graft function of kidney transplant recipients (without primary hyperoxaluria) with elevated plasma oxalate (POx) and enteric risk factors prior to transplant at our institution.

METHODS: Kidney transplant recipients between 2012 to 2020 with elevated POx at the time of kidney transplant evaluation were included. A matched control cohort was gathered using patient/donor age, living/deceased donor type, panel reactive antibody (PRA), kidney donor profile index (KDPI), and human leukocyte antigen (HLA) mismatch as matching variables. Graft function at 1 year and at last follow-up was reported.

RESULTS: A total of 106 patients with elevated POx were identified. A third of the patients had Roux-en-Y gastric bypass, a third had other enteric risks, and a third did not have an identifiable enteric risk. Median eGFR (estimated glomerular filtration rate) at 1-year and at last follow-up were similar between cases and controls except for subgroup of patients with pre-transplant POx >30mcmol/L where 1-year eGFR was lower compared to controls. Across eGFR categories, more cases were in eGFR category <30ml/min/1.73m2 compared to controls.

DISCUSSION/CONCLUSION: Roux-en-Y gastric bypass is the most common identifiable risk for elevated POx in kidney transplant candidates. 1-year graft function was not inferior in cases compared to matched controls except for subgroup with POx>30mcmol/L pre-transplant.