Add like
Add dislike
Add to saved papers

Association between Congenital Heart Disease and Parenteral Nutrition-Associated Liver Disease in Neonates: A retrospective cohort study.

OBJECTIVE: Infants receiving parenteral nutrition (PN) are at increased risk of PN associated liver disease (PNALD), which can lead to hepatic fibrosis. While congenital heart disease (CHD) represents a risk factor for hepatic fibrosis, this study sought to better understand if infants with CHD were at elevated risk of PNALD when receiving long-term PN.

STUDY DESIGN: A retrospective cohort of infants at a Level IV NICU from 2010 to 2020 who received long-term PN during the first 8 weeks of life. A time-varying cox-survival model was used to model risk of PNALD between CHD and non-CHD infants adjusted for demographics, surgical intervention, and PN exposure using a 5000-iteration bootstrap estimation. Secondary analyses evaluated risk against discrete CHD diagnoses, and sensitivity analysis was performed on the magnitude and quantity of direct bilirubin lab values comprising the PNALD definition.

RESULTS: Neonates with CHD were found to be at higher risk for PNALD during or quickly following long-term PN exposure. A pattern of increasing association strength with increasing bilirubin threshold suggests infants with CHD may also experience higher degrees of injury.

CONCLUSIONS: This work offers a step in understanding how diagnoses can be factored into neonate PN prescription. Future work will explore modifications in lipid profiles and timing to mitigate risk in patients with CHD. This article is protected by copyright. All rights reserved.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app