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Differential impact of glycation on Apolipoprotein A-I of high-density lipoprotein: a review.
Glycobiology 2023 Februrary 11
Hyperglycemia is a poorly controlled diabetic condition, affects about 70 percent of people all round the world. In the year 2015, about 41.5 crore people were diabetic and is expected to reach around 64.3 crore by the year 2040. Cardiovascular diseases (CVDs) are considered as one of the major risk factors that cause more than half of the death of diabetic patients and promote related comorbidities. Atherosclerosis and amyloidosis are the prime rudimentary cause associated with CVDs. Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) have protective action against CVDs, participate in reverse cholesterol transport (RCT) mechanism and lipid metabolism, but gets easily glycated under prolonged hyperglycemic aura i.e. glycation. ApoA-I have a potent role in maintenance of glucose level, providing a compelling link between diabetes and CVDs. Increased protein glycation in people with diabetes promote atherosclerosis which might play possible role in promotion of protein aggregation by altering the protein structure and its confirmation. Here, we intend to investigate the mechanistic behavior of ApoA-Iunder the menace of glycation and its impact on ApoA-I structure and function that possibly link with aggregation or amyloidosis.
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