The role of serial cardiac biomarkers in prognostication and risk prediction of chronic heart failure: additional scientific insights with hemodynamic feedback.

INTRODUCTION: Heart failure (HF) is considered as a chronic long-term and lethal disease, and will continue to be a major public health problem. Studying (circulating) biomarkers is a promising field of research and could be the first step towards HF tailored prognostic strategies as well as understanding the response to HF drugs in CHF patients.

AREAS COVERED: In literature, there has been considerable research on elevated biomarker levels that are related to a poor prognosis for HF. Since biomarker levels change over time, it is important to study serial (repeated) biomarker measurements which may help us better understand the dynamic course of HF illness. However, the majority of research focuses predominantly on baseline values of biomarkers. Additionally, remote monitoring devices, like sensors, can be used to link hemodynamic information to freshen biomarker data in order to further ameliorate the management of HF.

EXPERT OPINION: Novel biomarkers and additional scientific insights with hemodynamic feedback strongly aid in the prognostication and risk prediction of chronic HF.