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Effect of Adding l-Carnitine to Risperidone on Behavioral, Cognitive, Social, and Physical Symptoms in Children and Adolescents With Autism: A Randomized Double-Blinded Placebo-Controlled Clinical Trial.
Clinical Neuropharmacology 2023 Februrary 5
OBJECTIVES: The present research aimed to evaluate the effect of adding l-carnitine to risperidone in treating children and adolescents with autism spectrum disorder (ASD).
METHODS: In this randomized controlled clinical trial study, 50 ASD children and adolescents were divided into 2 groups: those receiving l-carnitine and risperidone (n = 25) and those receiving placebo and risperidone (n = 25). Treatment continued for 8 weeks, and participants were assessed at the beginning of the study, in the fourth and eighth weeks, by the Aberrant Behavior Checklist (ABC).
RESULTS: l-Carnitine add-on therapy reduced the scores of total ABC and subscales of restlessness, lethargy and social isolation, stereotypic behavior, and inappropriate speech at weeks 4 and 8. There was a significant difference between the 2 groups in the score of total ABC and subscale of lethargy and social isolation.
CONCLUSIONS: According to the present study, adding l-carnitine to risperidone improves ASD symptoms.
METHODS: In this randomized controlled clinical trial study, 50 ASD children and adolescents were divided into 2 groups: those receiving l-carnitine and risperidone (n = 25) and those receiving placebo and risperidone (n = 25). Treatment continued for 8 weeks, and participants were assessed at the beginning of the study, in the fourth and eighth weeks, by the Aberrant Behavior Checklist (ABC).
RESULTS: l-Carnitine add-on therapy reduced the scores of total ABC and subscales of restlessness, lethargy and social isolation, stereotypic behavior, and inappropriate speech at weeks 4 and 8. There was a significant difference between the 2 groups in the score of total ABC and subscale of lethargy and social isolation.
CONCLUSIONS: According to the present study, adding l-carnitine to risperidone improves ASD symptoms.
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