We have located links that may give you full text access.
Targeting Left Ventricular Mechanics In Patients With Pheochromocytoma/Paraganglioma: An Updated Meta-Analysis.
American Journal of Hypertension 2023 January 10
BACKGROUND AND AIM: Numerous studies targeting left ventricular (LV) systolic function by measuring LV ejection fraction (LVEF) in patients with pheochromocytoma and paraganglioma (PPGL) either failed to reveal any impairment of this parameter or found a super-normal systolic function compared to essential hypertensives or normotensive controls. In order to provide an updated piece of information on LV systolic dysfunction in the PPGL setting, we performed a meta-analysis of speckle tracking echocardiography (STE) studies investigating LV mechanics via global longitudinal strain (GLS), a more sensitive index of LV systolic function than LVEF.
METHODS: A computerized search was performed using Pub-Med, OVID, EMBASE and Cochrane library databases from inception until September, 30 st 2022. Full articles reporting data on LV GLS and LVEF in patients with PPGL and controls were considered suitable.
RESULTS: A total of 252 patients with PPGL and 187 controls were included in 6 studies.LV GLS was worse in the pooled PPGL group than in the control group (-17.3±1.2 vs -20.0±0.6) with a standard means difference (SMD) of 1.13±0.36 (CI: 0.43-1.84, p =0.002), whereas this was not the case for LVEF (67.3±1.9 and 66.4±1.6%, respectively), SMD: 0.12±0.03, CI: -0.41/0.65, p=0.66). A meta-regression analysis in PPGL patients showed an inverse relationship between adrenergic activity and GLS (p <0.0001).
CONCLUSIONS: Our findings suggest that early changes in LV systolic function not detectable by conventional echocardiography in the PPGL setting can be revealed by STE; therefore, STE implementation in the work-up of patients with PPGL may improve the detection subclinical systolic dysfunction.
METHODS: A computerized search was performed using Pub-Med, OVID, EMBASE and Cochrane library databases from inception until September, 30 st 2022. Full articles reporting data on LV GLS and LVEF in patients with PPGL and controls were considered suitable.
RESULTS: A total of 252 patients with PPGL and 187 controls were included in 6 studies.LV GLS was worse in the pooled PPGL group than in the control group (-17.3±1.2 vs -20.0±0.6) with a standard means difference (SMD) of 1.13±0.36 (CI: 0.43-1.84, p =0.002), whereas this was not the case for LVEF (67.3±1.9 and 66.4±1.6%, respectively), SMD: 0.12±0.03, CI: -0.41/0.65, p=0.66). A meta-regression analysis in PPGL patients showed an inverse relationship between adrenergic activity and GLS (p <0.0001).
CONCLUSIONS: Our findings suggest that early changes in LV systolic function not detectable by conventional echocardiography in the PPGL setting can be revealed by STE; therefore, STE implementation in the work-up of patients with PPGL may improve the detection subclinical systolic dysfunction.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app