Multidisciplinary Integrated Care in Atrial Fibrillation (MICAF): A Systematic Review and Meta-Analysis.

Objective: To assess the effectiveness of multidisciplinary integrated care in the clinical outcomes of atrial fibrillation patients. Methods: Medline, EMBASE, and the CENTRAL trials registry of the Cochrane Collaboration were searched for articles on multidisciplinary integrated care in atrial fibrillation patients. The systematic review and meta-analysis included six and five articles, respectively, that compared the outcomes between the integrated care group and control group. Results: Multidisciplinary integrated care was concomitant with a decrease in all-cause mortality (OR 0.52, 95%CI 0.36-0.74, P =0.0003) and cardiovascular hospitalization (OR 0.66, 95%CI 0.49-0.89, P =0.007). Multidisciplinary integrated care had no significant impact on major adverse cardiovascular event (MACE) (OR 0.76, 95%CI 0.37-1.53, P =0.44), cardiovascular deaths (OR 0.49, 95% CI 0.21-1.17, P =0.11), atrial fibrillation (AF)-related hospitalization (OR 0.76, 95%CI 0.53-1.09, P =0.14), major bleeding (OR 1.02, 95%CI 0.59-1.75, P =0.94), minor bleeding (OR 1.12, 95%CI 0.55-2.26, P =0.76), and cerebrovascular events (OR 0.72, 95%CI 0.45-1.18, P =0.19). Conclusion: In comparison to usual care, a multidisciplinary integrated care approach (i.e., nurse-led care along with usual specialist care) in AF patients is associated with reduced all-cause mortality and cardiovascular hospitalization.