Add like
Add dislike
Add to saved papers

Post colonoscopy cancer rate (PCCRC-3Y) at a tertiary referral hospital in Australia - A data linkage analysis.

INTRODUCTION: Colorectal cancer (CRC) diagnosed following a cancer-negative colonoscopy is termed as post-colonoscopy CRC (PCCRC). The World Endoscopy Organization has recently standardized definition of PCCRC-3Y (CRC developing within 3 years of a cancer-negative colonoscopy). In the present study, we sought to assess PCCRC-3Y rate, perform root-cause analyses and identify factors associated with development of PCCRC at a tertiary referral hospital in Australia.

METHODS: All patients undergoing colonoscopy from 2011 to 2018 were matched to a population-based cancer register. PCCRC-3Y rate was assessed for years 2011-2015. All PCCRC cases, that developed within 6-48 months after a cancer-negative colonoscopy underwent root-cause analyses. Descriptive statistics were used to summarize data.

RESULTS: Amongst 17,828 patients undergoing colonoscopy, 367 CRC cases were diagnosed during the study period. This included 9 PCCRC cases, which developed at a median of 14 months (range 7-34) after cancer-negative colonoscopy. The PCCRC-3Y rate for year 2011-2015 was 2.16% (95%CI 0.91-5.15). All 9 PCCRC cases were moderately or poorly differentiated adenocarcinomas. 7/9 were early-stage CRC (stage 1-2). 6/9 probably represented missed lesions at index colonoscopy despite an apparently adequate examination. History of inflammatory bowel disease (IBD) (OR 21.9, 95%CI 4.6-103.7, p<0.001) and diverticulosis (OR 5.4, 95%CI 1.4 - 20.5, p = 0.01) were significantly associated with development of missed CRC.

CONCLUSIONS: In our tertiary referral colonoscopy cohort, PCCRC-3Y rate was 2.16% (95%CI 0.91-5.15). IBD and diverticulosis were significantly associated with risk of PCCRC. The majority of PCCRC lesions were likely missed at index colonoscopy, despite an apparently adequate examination.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app