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Efficacy and Safety of Date Palm Leaf-based Ointment for Treatment of Cutaneous Warts: A Pilot Clinical Trial.
Dermatologic Therapy 2022 November 9
INTRODUCTION: Despite the considerably high prevalence of cutaneous warts, no optimally effective and safe treatment is available. Leaves of date palm (Phoenix dactylifera L.; Arecaceae) have long been used in Iran's folk medicine as a remedy for warts.
METHODS: To assess the state-of-the-art evidence on using P. dactylifera L. for warts, we conducted a systematic review using CINAHL (using EBSCO), Embase, Medline (using PubMed), ProQuest, Scopus, and Web of Science. We conducted an open-label uncontrolled pilot clinical study to evaluate the efficacy and safety of a proprietary topical date palm leaf-based ointment for the treatment of various types of non-genital warts. This study consisted of an 8-week treatment phase and a 4-week follow-up phase. The assessed outcomes included complete clearance, patient satisfaction (on Likert scale), and the occurrence of any adverse effect.
RESULTS: The systematic review demonstrated that the effects of date palm on warts have not been scientifically studied. 30 patients entered the study with a mean age of 29.5 years (SD=14.04) among which 17 were female and 13 were male. The patients presented diverse types of warts: Verruca vulgaris 15 (50%), Plantar 9 (30%), Plane 2 (7%), Periungual 2 (7%), and warts at multiple sites 2 (7%). In this trial, 19 patients (63.3%) experienced complete clearance and 5 patients (16.6%) experienced partial clearance. Eight patients (26.67%) dropped out during the study. 21 (70%) patients were very satisfied (score on Likert scale = 5) while 1 (3.3%) patient with partial clearance was somewhat satisfied (score on Likert scale = 4). No adverse effect was observed.
CONCLUSION: The results of this pilot study indicate that the date palm leaf-based ointment is a promising treatment whose efficacy and safety should be further investigated in a randomized controlled clinical trial. This article is protected by copyright. All rights reserved.
METHODS: To assess the state-of-the-art evidence on using P. dactylifera L. for warts, we conducted a systematic review using CINAHL (using EBSCO), Embase, Medline (using PubMed), ProQuest, Scopus, and Web of Science. We conducted an open-label uncontrolled pilot clinical study to evaluate the efficacy and safety of a proprietary topical date palm leaf-based ointment for the treatment of various types of non-genital warts. This study consisted of an 8-week treatment phase and a 4-week follow-up phase. The assessed outcomes included complete clearance, patient satisfaction (on Likert scale), and the occurrence of any adverse effect.
RESULTS: The systematic review demonstrated that the effects of date palm on warts have not been scientifically studied. 30 patients entered the study with a mean age of 29.5 years (SD=14.04) among which 17 were female and 13 were male. The patients presented diverse types of warts: Verruca vulgaris 15 (50%), Plantar 9 (30%), Plane 2 (7%), Periungual 2 (7%), and warts at multiple sites 2 (7%). In this trial, 19 patients (63.3%) experienced complete clearance and 5 patients (16.6%) experienced partial clearance. Eight patients (26.67%) dropped out during the study. 21 (70%) patients were very satisfied (score on Likert scale = 5) while 1 (3.3%) patient with partial clearance was somewhat satisfied (score on Likert scale = 4). No adverse effect was observed.
CONCLUSION: The results of this pilot study indicate that the date palm leaf-based ointment is a promising treatment whose efficacy and safety should be further investigated in a randomized controlled clinical trial. This article is protected by copyright. All rights reserved.
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