Early Postoperative Organ Dysfunction is Highly Associated with the Mortality Risk of Patients with Type A Aortic Dissection.

OBJECTIVES: This study assessed the impact of early postoperative organ dysfunction (EPOD) on in-hospital mortality of patients with type A aortic dissection (TAAD) after surgery.

METHODS: Patients with TAAD who underwent surgical repair requiring deep hypothermic circulatory arrest from January 2020 to December 2021 were included. The Sequential Organ Failure Assessment (SOFA) score was calculated for three days postoperatively to stratify the severity of organ dysfunction. Patients with SOFA of 0-4, 5-8 or > 8 were defined as mild, moderate or severe EPOD. The primary outcome was in-hospital mortality, and a composite secondary outcome was defined as in-hospital death or any major complications. Kaplan-Meier curves were used to compare survival probability. The area under the receiver operating characteristic curve (AUROC) and calibration plots were used to evaluate the predictive power and overall performance of SOFA.

RESULTS: Of the 368 patients, 5 patients (3%) with moderate EPOD and 33 patients (23%) with severe EPOD died. No patient died with mild EPOD. The AUROCs of SOFA for predicting mortality and the composite outcome were 0.85(0.81-0.88) and 0.81(0.77-0.85) on postoperative day 1. Each point of postoperative day 1 SOFA score corresponded to an odds ratio of 1.65 (1.42-1.92) for mortality. Of the six components of the SOFA system, only coagulation (2.34[1.32-4.13]), cardiovascular (1.47[1.04-2.08]), central nervous system (1.96[1.36-2.82]) and renal (1.67[1.04-2.70]) functions were associated with higher risk of mortality.

CONCLUSIONS: EPOD stratified by the SOFA score was associated with higher risk of death and predicted the clinical outcomes of patients with TAAD with good accuracy.