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TIGIT Monoallelic Nonsense Variant in Patient with Severe COVID-19 Infection, Thailand.
Emerging Infectious Diseases 2022 October 4
A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient's T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity.
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