JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Number of mitral cells and the bulb volume in the aging human olfactory bulb: a quantitative morphological study.
Anatomical Record 1987 May
The present study documents the morphological changes in the aging human olfactory bulb. Eight bulb pairs from white females between the ages of 25 and 102 years were used. The number of mitral cells in layers IV and III was determined for each bulb and corrected for split cell error. Counts were made on 10-micron thick Nissl-stained sections at 250-micron intervals. The mean number of mitral cells per olfactory bulb at age 25 was estimated from linear regression to be 50,935; at age 60, 32,718; and at age 95, 14,501. The average loss over the time interval studied was 520 mitral cells per year. The volume of each bulb layer, except layer IV, was determined. The difference in the volume of each layer within individuals with age and the total volume with age was not significant (P less than 0.11). The estimated mean bulb volume was found to be 50.02, 43.35, and 36.68 mm3 at ages 25, 60, and 95 years, respectively. The estimated reduction in bulb volume per year increase of age was 0.19 mm3. The ratio of mitral cells to bulb volume for layer III decreased by 19.4 units for every year increase in age. No significant difference was found between the left and the right bulbs in regard to the number of mitral cells and the bulb volume. Histologically, the glomerular layer thickness as well as the mitral cell size and concentration per unit area decreased with age. The intrabulbar anterior olfactory nucleus was discontinuous, highly variable in size, and presumably variable even in neuronal numbers.
Full text links
Trending Papers
Abdominal wall closure.British Journal of Surgery 2023 September 16
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
Read by QxMD is copyright © 2021 QxMD Software Inc. All rights reserved. By using this service, you agree to our terms of use and privacy policy.
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app