Germ cell tumors of the ovary: the experience of the National Cancer Institute of Milan. I. Dysgerminoma

G De Palo, A Lattuada, R Kenda, R Musumeci, M Zanini, S Pilotti, F F Bellani, F Di Re, A Banfi
International Journal of Radiation Oncology, Biology, Physics 1987, 13 (6): 853-60
The experience of the Istituto Nazionale Tumori of Milan on dysgerminoma is presented. Between 1970 and December of 1982, 25 patients were treated with a unique protocol which considered surgery and radiotherapy with different schedules according to the extension of the disease. With this treatment protocol all 13 patients at Stage I were alive and free of disease with a median follow-up of 77 months. Of 12 patients at Stage III (10 retroperitoneal and 2 retroperitoneal and peritoneal) 4 relapsed. The 5-year relapse-free survival of Stage III patients was 61.4% and the overall survival 89.5%. Amenorrhea due to radiation dose absorbed by the contralateral shielded ovary was found in 7.7%. The excellent results in Stage I patients were balanced by the unsatisfactory results in Stage III patients. A more aggressive treatment and the knowledge of other prognostic factors seem necessary.

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