Light Chain Deposition Disease: An Unusual Cause of Portal Hypertension

Molly Delk Plummer, Fredric Regenstein
Hepatology: Official Journal of the American Association for the Study of Liver Diseases 2021, 74 (6): 3546-3548
Light chain deposition disease (LCDD) is a rare entity that is generally discovered in the setting of solid organ dysfunction. The monoclonal gammopathy leads to abnormal deposition of light chains in tissues, most often manifested by way of renal dysfunction. Other organ systems may also be affected, the liver being the second-most common after the kidneys. Liver involvement rarely leads to clinically significant disease, with few case reports in the literature. We present the case of a patient referred to a hepatology clinic for the evaluation of new-onset ascites resulting from portal hypertension secondary to LCDD involving the liver.

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