Sclerema neonatorum: a sign of transient hyperammonemia of the newborn

J A Lindenberg, J M Milstein, K L Cox
Journal of Pediatric Gastroenterology and Nutrition 1987, 6 (3): 474-6
We cared for four neonates with transient hyperammonemia of the newborn (THAN), all of whom exhibited sclerema during their course. Sclerema is a hardening of the subcutaneous tissues, which gives the tissue a firm, rubber-like quality. This association has not been previously reported, and it may provide a clue to early diagnosis and intervention in THAN.

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