We have located links that may give you full text access.
A novel method for the quantification of anlotinib in human plasma using two-dimensional liquid chromatography.
Biomedical Chromatography : BMC 2021 July 23
A simple, efficient and stable detection method of two-dimensional liquid chromatography(2D-LC) was established and validated for the determination of anlotinib in human plasma. The 2D-LC system comprises a first-dimensional column (LC1), an intermediate transfer column and a second-dimensional column (LC2). With simple protein precipitation treatment, the samples were processed directly for detecting. The analysis cycle time was completed within 9.50 min. The calibration curve was linear over the 5.00-320.00 ng/mL range for the anlotinib concentrations. The intra-day and inter-day precisions ranges were 0.77-6.22% and 1.92-4.26% for anlotinib concentration. The recoveries were in the range from 97.85 to 102.50%. A total of 135 plasma samples from 94 patients were analyzed by our method. The plasma concentrations of patients were in the range 5.17-106.38 ng/mL in which the female had higher plasma concentration (6.44-106.38 ng/mL). The simultaneous application of dexamethasone can increase the plasma drug of anlotinib concentration. In our clinical application, we found that the factors which affect plasma concentration include time and dose of medication, gender and drug interactions. The method appears to be sensitive, precise, selective, and suitable for determining the concentration of anlotinib in plasma sample.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app